ATF2 orchestrates macrophage differentiation and activation to promote antibacterial responses.

Rajabalee N, Siushansian H, Weerapura M, Berton S, Berbatovci F, Hooks B, Geoffrion M, Yang D, Harper ME, Rayner K, Blais A, Sun J. J Leukoc Biol qiad076.

Mycobacterium tuberculosis infection triggers epigenetic changes that are enriched in a type I IFN signature

Madden K, El Hamra R, Berton S, Felker J, Alvarez GG, Blais A, Sun J. microLife 4:uqad006.


Discovery of benzo[c]phenanthridine derivatives with potent activity against multidrug resistant Mycobacterium tuberculosis.

Sun Z, Liang YC, Lu C, Lupien A, Xu Z, Berton S, Behr MA, Yang W, Sun J. bioRxiv 11.07.515485.


TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages.

Dabla A, Liang YC, Rajabalee N, Irwin C, Moonen CGJ, Willis JV, Berton S, Sun J. mBio 13(4):e0145622.

An in vivo biosafety-level-2-compatible model of Mycobacterium tuberculosis infection for drug susceptibility testing.

Liang YC*, Berton S*, Reeks C, Sun J. STAR Protoc 3(3):101575. *equal contributions

A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis.

Berton S*, Chen L*, Liang YC*, Xu Z, Afriyie-Asante A, Rajabalee N, Yang W, Sun J. Cell Chem Biol 29(7):1126-1139.e12. *equal contributions

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Surveying the epigeneticlandscape of tuberculosis in alveolar macrophages.

Madden K, Liang YC*, Rajabalee N*, Alvarez GG, Sun J. Infect Immun 90(5):e0052221. *equal contributions


Mycobacterium tuberculosis Exploits Focal Adhesion Kinase to Induce Necrotic Cell Death and Inhibit Reactive Oxygen Species Production.

Afriyie-Asante A, Dabla A, Dagenais A, Berton S, Smyth R, Sun J. Front Immunol 12:742370.

Protein Kinase R in Bacterial Infections: Friend or Foe?

Smyth R and Sun J. Front Immunol 12:702142.

Protein Kinase R restricts the intracellular survival of Mycobacterium tuberculosis by promoting selective autophagy.

Smyth R, Berton S, Rajabalee N, Chan T, Sun J. Front Microbiol 11:613963.


Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7.

Dennis EA, Smythies LE, Grabski R, Li M, Ballestas ME, Shimamura M, Sun J, Grams J, Stahl R, Niederweis ME, Britt WJ, Smith PD. Mucosal Immunol 11(6):1694-1704.


NAD depletion triggers macrophage necroptosis, a cell Death pathway exploited by mycobacterium tuberculosis.

Pajuelo D, Gonzalez-Juarbe N, Tak U, Sun J, Orihuela CJ, Niederweis M. Cell Rep 24(2):429-440.

The phosphatase PPM1A controls monocyte-to-macrophage differentiation.

Smith SR, Schaaf K, Rajabalee N, Wagner F, Duverger A, Kutsch O, Sun J. Sci Rep 8(1):902.


Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis.

Schaaf K, Smith SR, Duverger A, Wagner F, Wolschendorf F, Westfall AO, Kutsch O, Sun J. Sci Rep 7:42101.

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High-throughput assay to evaluate drug efficacy against macrophage passaged Mycobacterium tuberculosis.

Schaaf K, Smith SR, Hayley V, Kutsch O, Sun J. J Vis Exp (121).


8-hydroxyquinolines are boosting-agents of copper related toxicity in Mycobacterium tuberculosis.

Shah S, Dalecki AG, Malalasekera A, Crawford C, Michalek S, Kutsch O, Sun J, Bossman S and Wolschendorf F. Antimicrob Agents Chemother 60(10):5765-76.

A macrophage infection model to predict drug efficacy against Mycobacterium tuberculosis.

Schaaf K, Hayley V, Wolschendorf F, Speer A, Niederweis M, Kutsch O, Sun J. Assay Drug Dev Technol 14(6):345-54.


Protein Phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection.

Sun J*, Schaaf K, Duverger A, Wolschendorf F, Speer A, Wagner F, Niederweis M and Kutsch O. Oncotarget 7(13):15394-15409. *co-corresponding author


The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD+. 

Sun J, Siroy A, Lokareddy RK, Speer A, Doornbos KS, Cingolani G, Niederweis M. Nature Struct Mol Biol 22(9):672-8.

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Surface hydrolysis of sphingomyelin by the outer membrane protein Rv0888 supports replication of Mycobacterium tuberculosis in macrophages.

Speer A, Sun J, Danilchanka O, Meikle V, Rowland JL, Walter K, Buck BR, Pavlenok M, Holscher C, Ehrt S, Niederweis M. Mol Microbiol 97(5):881-97.


An outer membrane channel protein of Mycobacterium tuberculosis with exotoxin activity.

Danilchanka O, Sun J, Pavlenok M, Maueröder C, Speer A, Siroy A, Marrero J, Trujillo C, Mayhew DL, Doornbos KS, Muñoz LE, Herrmann M, Ehrt S, Berens C, Niederweis M. Proc Natl Acad Sci USA 6;111(18):6750-5.


Mycobacterium tuberculosis nucleoside diphosphate kinase inactivates small GTPases leading to evasion of innate immunity.

Sun J, Singh V, Lau A, Stokes RW, Obregón-Henao A, Orme IM, Wong D, Av-Gay Y, Hmama Z. PLoS Pathog 9(7):e1003499.


Mycobacterial nucleoside diphosphate kinase blocks phagosome maturation in murine RAW 264.7 macrophages.

Sun J, Wang X, Lau A, Liao TY, Bucci C, Hmama Z. PLoS ONE 5(1), e8769.


A broad-range of recombination cloning vectors in mycobacteria.

Sun J, Lau A, Wang X, Liao TY, Zoubeidi A, Hmama Z. Plasmid 62(3), 158-65.


Detection of Activated Rab7 GTPase with an Immobilized RILP Probe.

Sun J, Deghmane AE, Bucci C, Hmama Z. Methods Mol Biol 531, 57-69.


Mycobacterium bovis BCG disrupts the interaction of Rab7 with RILP contributing to inhibition of phagosome maturation.

Sun J, Deghmane AE, Soualhine H, Hong T, Bucci C, Solodkin A, Hmama Z. J Leuk Biol 82(6), 1437-1445.


Mycobacterium bovis bacillus Calmette-Guérin secreting active cathepsin S stimulates expression of mature MHC class II molecules and antigen presentation in human macrophages.

Soualhine H, Deghmane AE, Sun J, Mak K, Talal A, Av-Gay Y, Hmama Z. J Immunol 15;179(8):5137-45.