We are a cellular microbiology lab studying how bacterial pathogens evade our immune system, using advanced imaging, flow cytometry, multi-omics and functional genomics approaches. Our research provides unique promise to develop host-directed therapeutic approaches to combating emerging and pandemic-level threats such as tuberculosis.
Principal Investigator
Jim obtained his BSc (2006) and PhD (2012) from the University of British Columbia and completed a postdoctoral fellowship at the University of Alabama at Birmingham. He began his independent faculty career at the University of Ottawa, where he established a dynamic TB research program from 2017 to 2023. In January 2024, Jim was recruited back to UBC in the Department of Microbiology and Immunology, and he now also serves as Associate Dean, Research and Partnerships in the Faculty of Science. His most significant research contributions have revealed how Mycobacterium tuberculosis evades the host immune response, led to the development of novel treatments for pathogenic infections, and identified the tuberculosis necrotizing toxin — work that have important implications for advancing host-directed therapies against tuberculosis. Jim has received multiple early career research awards, including from Pfizer Canada, the Canadian Society for Immunology, ASM, and the Lung Health Foundation.